Journal: JOR Spine
Article Title: Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration
doi: 10.1002/jsp2.1365
Figure Lengend Snippet: Fibrosis progression alters tissue microstructure and biochemical composition. (A) X‐ray diffraction (XRD) patterns demonstrate collagen/elastin and mineral presence changes in grade 2 fibrosis, with hydroxyapatite crystals appearing in grade 3 fibrosis. Each graph represents the average of four samples per fibrosis grade (B) Average Raman spectra from all tissue with different grades highlight biochemical shifts across fibrosis grades (VG1‐3, DG1‐3), including alterations in proline/hydroxyproline (peaks 1 and 2), phosphate (peak 3), proteoglycan groups (peaks 4 and 5), and amide I groups (peak 6) which became the focus of this study. DG, Dorsal Grade; VG, Ventral Grade.
Article Snippet: LF phase changes due to degeneration were analyzed using X‐ray diffraction (XRD) with a two‐dimensional X‐ray diffractometer: D8 Discover with GADDS (Bruker AXS Gmbh, Karlsruhe, Germany).
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